The world's first analgesic with no side effects has successfully passed the preclinical trials. The innovative drug was created by a scientific group that included specialists from TSU, IPCET SB RAS, and the Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg. The basis for the analgesic, which has no analogs, was the modified molecule of the powerful explosive CL-20.
Three-year studies of the properties of the new drug, called thiowurcin, were carried out by specialists of the Goldberg Research Institute on mice, rats, rabbits, guinea pigs, and Drosophila. The strength and duration of exposure to thiowurcin were superior to many known analgesics and could effectively relieve pain of any etiology. Along with the effectiveness, the pharmacologists studied the degree of toxic effects in animals to predict side effects in humans.
Along with this, the effect of thiowurcin on the immune system and reproductive function of animals after administration, which lasted from two weeks to three months, was studied. No genotoxic and mutagenic effects leading to DNA damage were detected. The data obtained indicate the safety of its use by men and women planning childbearing.
Now developers have to go through the last and most expensive stage - clinical trials of the drug. The cost of research, giving an objective picture, starts from half a billion rubles. That is why a considerable part of the new pharmacological developments simply does not reach the pharmacy. Currently, research organizations - the creators of thiowurcin - are negotiating with several pharmaceutical companies, including abroad, and are looking for an investor who will be ready to finance clinical trials.
According to the developers, an innovative drug may help solve the global problem facing the whole world, especially the United States - this is an opioid crisis caused by the intake of synthesized analgesics. Their consumers are primarily people with chronic pain who are forced to take powerful painkillers for several months or even constantly, which are highly addictive and can lead to death if overdosed.